2381/37341 Guosheng Tan Guosheng Tan Linwei Wu Linwei Wu Jinfu Tan Jinfu Tan Bing Zhang Bing Zhang William Chi-shing Tai William Chi-shing Tai Shiqiu Xiong Shiqiu Xiong Wei Chen Wei Chen Jianyong Yang Jianyong Yang Heping Li Heping Li MiR-1180 promotes apoptotic resistance to human hepatocellular carcinoma via activation of NF-κB signaling pathway University of Leicester 2016 IR content 2016-04-18 11:36:10 Journal contribution https://figshare.le.ac.uk/articles/journal_contribution/MiR-1180_promotes_apoptotic_resistance_to_human_hepatocellular_carcinoma_via_activation_of_NF-_B_signaling_pathway/10138343 Apoptosis resistance in human hepatocellular carcinoma (HCC) is a significant factor in carcinogenesis. Therefore, understanding the molecular mechanisms involved in apoptosis resistance is crucial for developing anticancer therapies. Importantly, small non-coding microRNAs (miRNAs) have been reported as key biomarkers for detecting tumour onset and progression. In the present study, we demonstrate that miR-1180 is upregulated in HCC. Ectopic expression of miR-1180 has an anti-apoptotic effect in HCC, while miR-1180 inhibition increases cell apoptosis, both in vitro and in vivo. Moreover, our results show that miR-1180 directly targets key inhibitors of the nuclear factor (NF)-κB signaling pathway (i.e., OTUD7B and TNIP2) and the pro-apoptotic Bcl-2 associated death promoter (BAD) protein by post-transcriptional downregulation. Therefore, the anti-apoptotic function of miR-1180 in HCC may occur through NF-κB pathway activation via downregulation of its negative regulators. In conclusion, our study reveals the critical role of miR-1180 during apoptosis resistance in HCC.