%0 Journal Article %A Sweeney, David %A Hollins, Fay %A Gomez, Edith %A Saunders, Ruth Mary %A Challiss, R.A. John %A Brightling, Christopher E. %D 2016 %T [Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma. %U https://figshare.le.ac.uk/articles/journal_contribution/_Ca2_i_oscillations_in_ASM_relationship_with_persistent_airflow_obstruction_in_asthma_/10144571 %2 https://figshare.le.ac.uk/ndownloader/files/18282449 %K airway hyperresponsiveness %K airway smooth muscle %K asthma %K calcium %K oscillations %K Adult %K Aged %K Asthma %K Biopsy %K Caffeine %K Calcium Signaling %K Case-Control Studies %K Female %K Forced Expiratory Volume %K Humans %K Male %K Middle Aged %K Muscle, Smooth %K Nitrendipine %K Pulmonary Disease, Chronic Obstructive %K Respiratory Muscles %K Severity of Illness Index %K Verapamil %K Vital Capacity %X The cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation. %I University of Leicester