2381/36445 T. M. Andersson T. M. Andersson P. W. Dickman P. W. Dickman S. Eloranta S. Eloranta A. Sjövall A. Sjövall M. Lambe M. Lambe Paul Christopher Lambert Paul Christopher Lambert The loss in expectation of life after colon cancer: a population-based study University of Leicester 2016 Colon cancer Survival Life expectancy Population-based Flexible parametric model Life years lost Sweden 2016-01-28 11:09:05 Journal contribution https://figshare.le.ac.uk/articles/journal_contribution/The_loss_in_expectation_of_life_after_colon_cancer_a_population-based_study/10145447 BACKGROUND: To demonstrate how assessment of life expectancy and loss in expectation of life can be used to address a wide range of research questions of public health interest pertaining to the prognosis of cancer patients. METHODS: We identified 135,092 cases of colon adenocarcinoma diagnosed during 1961-2011 from the population-based Swedish Cancer Register. Flexible parametric survival models for relative survival were used to estimate the life expectancy and the loss in expectation of life. RESULTS: The loss in expectation of life for males aged 55 at diagnosis was 13.5 years (95 % CI 13.2-13.8) in 1965 and 12.8 (12.4-13.3) in 2005. For males aged 85 the corresponding figures were 3.21 (3.15-3.28) and 2.10 (2.04-2.17). The pattern was similar for females, but slightly greater loss in expectation of life. The loss in expectation of life is reduced given survival up to a certain time point post diagnosis. Among patients diagnosed in 2011, 945 life years could potentially be saved if the colon cancer survival among males could be brought to the same level as for females. CONCLUSION: Assessment of loss in expectation of life facilitates the understanding of the impact of cancer, both on individual and population level. Clear improvements in survival among colon cancer patients have led to a gain in life expectancy, partly due to a general increase in survival from all causes.