2381/36275
E. D. Micewicz
E. D.
Micewicz
O. S. Bahattab
O. S.
Bahattab
Gary Brian Willars
Gary Brian
Willars
A. J. Waring
A. J.
Waring
M. Navab
M.
Navab
J. P. Whitelegge
J. P.
Whitelegge
W. H. McBride
W. H.
McBride
P. Ruchala
P.
Ruchala
Small lipidated anti-obesity compounds derived from neuromedin U
University of Leicester
2016
Antiobesity agents
Lipid-conjugated peptides
Neuromedin U receptor agonists
Obesity
2016-01-13 09:53:40
Journal contribution
https://figshare.le.ac.uk/articles/journal_contribution/Small_lipidated_anti-obesity_compounds_derived_from_neuromedin_U/10152398
A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. The most promising compound, NM4-C16 was effective in a once-weekly-dose regimen. Collectively, our findings suggest that short, lipidated analogs of NmU are suitable leads for the development of novel anti-obesity therapeutics.