%0 Journal Article %A Booth, Susan E. %A Jenkins, Paul R. %A Swain, Christopher J. %D 2016 %T The Preparation and Intramolecular Radical Cyclisation Reactions of Chiral Oxime Ethers %U https://figshare.le.ac.uk/articles/journal_contribution/The_Preparation_and_Intramolecular_Radical_Cyclisation_Reactions_of_Chiral_Oxime_Ethers/10162553 %2 https://figshare.le.ac.uk/ndownloader/files/18314966 %K racemic hydroxylamines %K oxime ester %K intramolecular reactions %K radical cyclizations %K chiral oxime ether %X Chiral oxime ether 2 and Oxime ester 4 have been prepared by alkylation and esterification of the oxime 1. Racemic hydroxylamine 6 and chiral hydroxylamine 10 have been synthesised from N-hydroxysuccinimide and the corresponding alcohol in the presence of diethylazodicarboxylate, the two products were converted into the oxime ethers 7 and 11 respectively. The intramolecular radical cyclisation reactions of these oxime ethers and esters has been studied, successful reaction was observed to produce alkyl hydroxylamines 3, 8 and 12. O éter-oxima quiral 2 e o éster-oxima 4 foram preparados para alquilação e esterificação da oxina 1. Hidroxiamina racêmica 6 e a hidroxiamina 10 foram sintetisadas a partir de N-hidroxipucanimida e o álcool correspondente na presença de di etil azodicarboxilato, e os dois produtos convertidos nos éteres-oximas 7 e 11 respectivamente. As reações de ciclização radicalar intramoleculares desses éteres e ésteres-oxima foram estudadas; a formação das alquil hidróxi-aminas 3, 8 e 12 foi observada nas reações bem sucedidas. %I University of Leicester