%0 Journal Article %A Takeuchi, F %A Akiyama, M %A Matoba, N %A Katsuya, T %A Nakatochi, M %A Tabara, Y %A Narita, A %A Saw, W-Y %A Moon, S %A Spracklen, CN %A Chai, J-F %A Kim, Y-J %A Zhang, L %A Wang, C %A Li, H %A Wu, J-Y %A Dorajoo, R %A Nierenberg, JL %A Wang, YX %A He, J %A Bennett, DA %A Takahashi, A %A Momozawa, Y %A Hirata, M %A Matsuda, K %A Rakugi, H %A Nakashima, E %A Isono, M %A Shirota, M %A Hozawa, A %A Ichihara, S %A Matsubara, T %A Yamamoto, K %A Kohara, K %A Igase, M %A Han, S %A Gordon-Larsen, P %A Huang, W %A Lee, NR %A Adair, LS %A Hwang, MY %A Lee, J %A Chee, ML %A Sabanayagam, C %A Zhao, W %A Liu, J %A Reilly, DF %A Sun, L %A Huo, S %A Edwards, TL %A Long, J %A Chang, L-C %A Chen, C-H %A Yuan, J-M %A Koh, W-P %A Friedlander, Y %A Kelly, TN %A Bin Wei, W %A Xu, L %A Cai, H %A Xiang, Y-B %A Lin, K %A Clarke, R %A Walters, RG %A Millwood, IY %A Li, L %A Chambers, JC %A Kooner, JS %A Elliott, P %A van der Harst, P %A Consortium, International Genomics of Blood Pressure %A Chen, Z %A Sasaki, M %A Shu, X-O %A Jonas, JB %A Heng, C-K %A Chen, Y-T %A Zheng, W %A Lin, X %A Teo, Y-Y %A Tai, E-S %A Cheng, C-Y %A Wong, TY %A Sim, X %A Mohlke, KL %A Yamamoto, M %A Kim, B-J %A Miki, T %A Nabika, T %A Yokota, M %A Kamatani, Y %A Kubo, M %A Kato, N %D 2019 %T Interethnic analyses of blood pressure loci in populations of East Asian and European descent. %U https://figshare.le.ac.uk/articles/journal_contribution/Interethnic_analyses_of_blood_pressure_loci_in_populations_of_East_Asian_and_European_descent_/10200605 %2 https://figshare.le.ac.uk/ndownloader/files/18384557 %K Asian Continental Ancestry Group %K Blood Pressure %K Continental Population Groups %K Europe %K European Continental Ancestry Group %K Female %K Genetic Loci %K Genome-Wide Association Study %K Humans %K Linkage Disequilibrium %K Male %K Polymorphism, Single Nucleotide %X Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max Nā€‰=ā€‰289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. %I University of Leicester