Takeuchi, F Akiyama, M Matoba, N Katsuya, T Nakatochi, M Tabara, Y Narita, A Saw, W-Y Moon, S Spracklen, CN Chai, J-F Kim, Y-J Zhang, L Wang, C Li, H Wu, J-Y Dorajoo, R Nierenberg, JL Wang, YX He, J Bennett, DA Takahashi, A Momozawa, Y Hirata, M Matsuda, K Rakugi, H Nakashima, E Isono, M Shirota, M Hozawa, A Ichihara, S Matsubara, T Yamamoto, K Kohara, K Igase, M Han, S Gordon-Larsen, P Huang, W Lee, NR Adair, LS Hwang, MY Lee, J Chee, ML Sabanayagam, C Zhao, W Liu, J Reilly, DF Sun, L Huo, S Edwards, TL Long, J Chang, L-C Chen, C-H Yuan, J-M Koh, W-P Friedlander, Y Kelly, TN Bin Wei, W Xu, L Cai, H Xiang, Y-B Lin, K Clarke, R Walters, RG Millwood, IY Li, L Chambers, JC Kooner, JS Elliott, P van der Harst, P Consortium, International Genomics of Blood Pressure Chen, Z Sasaki, M Shu, X-O Jonas, JB Heng, C-K Chen, Y-T Zheng, W Lin, X Teo, Y-Y Tai, E-S Cheng, C-Y Wong, TY Sim, X Mohlke, KL Yamamoto, M Kim, B-J Miki, T Nabika, T Yokota, M Kamatani, Y Kubo, M Kato, N Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max Nā€‰=ā€‰289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. Asian Continental Ancestry Group;Blood Pressure;Continental Population Groups;Europe;European Continental Ancestry Group;Female;Genetic Loci;Genome-Wide Association Study;Humans;Linkage Disequilibrium;Male;Polymorphism, Single Nucleotide 2019-08-15
    https://figshare.le.ac.uk/articles/journal_contribution/Interethnic_analyses_of_blood_pressure_loci_in_populations_of_East_Asian_and_European_descent_/10200605