Nonsyndromic Parkinson disease in a family with autosomal dominant optic atrophy due to OPA1 mutations LynchDS LohSH HarleyJ NoyceAJ MartinsLM WoodNW HouldenH Plun-FavreauH 2019 Many genes implicated in familial Parkinson disease (PD) code for proteins with mitochondrial function.1 Several of these genes, including PINK1 and PARK2, are involved in mitophagy, a mitochondrial quality control pathway.2 We describe a family with 3 members affected by autosomal dominant optic atrophy in which 2 affected members also developed PD. While the role of mitophagy-related genes in PD is well established, this report provides further evidence of PD risk conferred through abnormal mitochondrial fusion and cristae morphology.