%0 Journal Article %A Tabasso, A. F. S. %A Jones, D. J. L. %A Jones, G. D. D. %A Macip, S. %D 2019 %T Radiotherapy-Induced Senescence and its Effects on Responses to Treatment. %U https://figshare.le.ac.uk/articles/journal_contribution/Radiotherapy-Induced_Senescence_and_its_Effects_on_Responses_to_Treatment_/10214807 %2 https://figshare.le.ac.uk/ndownloader/files/18419333 %K Adjuvant therapy %K Radiotherapy %K Senescence %K Senolytics %X Radiotherapy is still a treatment of choice for many malignancies, often in combination with other strategies. However, its efficacy is limited by the dose that can be safely administered without eliciting serious side-effects, as well as the fact that recurrence is common, particularly in large tumours. Combining radiotherapy with drugs that could sensitise cells to radiation and/or reduce the factors that promote the recovery of the surviving cancer cells is a promising approach. Ionising radiation has been shown to induce senescence and the accumulation of senescent cells creates a microenvironment that facilitates neoplastic growth. This provides a rationale to test the addition of anti-senescent drugs, some of which are already available in the clinic, to radiotherapy protocols. Here, we discuss the relevance of radiotherapy-induced senescent cell accumulation and the potential interventions to minimise its negative effects. %I University of Leicester