Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol Harsimran K. Minhas William Riley Alison M. Stuart Martyna Urbonaite 2381/44074 https://figshare.le.ac.uk/articles/journal_contribution/Activation_of_the_hypervalent_fluoroiodane_reagent_by_hydrogen_bonding_to_hexafluoroisopropanol/10241045 Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions. 2019-05-14 11:02:44 IR content