Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol
Harsimran K. Minhas
William Riley
Alison M. Stuart
Martyna Urbonaite
2381/44074
https://figshare.le.ac.uk/articles/journal_contribution/Activation_of_the_hypervalent_fluoroiodane_reagent_by_hydrogen_bonding_to_hexafluoroisopropanol/10241045
Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
2019-05-14 11:02:44
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