%0 Journal Article %A Cai, Yutong %A Hansell, Anna L %A Granell, Raquel %A Blangiardo, Marta %A Zottoli, Mariagrazia %A Fecht, Daniela %A Gulliver, John %A Henderson, A John %A Elliott, Paul %D 2020 %T Prenatal, Early-life and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort. %U https://figshare.le.ac.uk/articles/journal_contribution/Prenatal_Early-life_and_Childhood_Exposure_to_Air_Pollution_and_Lung_Function_The_ALSPAC_Cohort_/11961237 %2 https://figshare.le.ac.uk/ndownloader/files/21960774 %K ALSPAC %K Air pollution %K children %K lung function %K traffic %X RATIONALE:Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. OBJECTIVES:To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. METHODS:Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. MEASUREMENTS AND MAIN RESULTS:We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. CONCLUSIONS:Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years. %I University of Leicester