The evolutionary history of dogs in the Americas Maire Ni Leathlobhair Angela R Perri Evan K Irving-Pease Kelsey E Witt Anna Linderholm James Haile Ophelie Lebrasseur Carly Ameen Jeffrey Blick Adam R Boyko Selina Brace Yahaira Nunes Cortes Susan J Crockford Alison Devault Evangelos A Dimopoulos Morley Eldridge Jacob Enk Shyam Gopalakrishnan Kevin Gori Vaughan Grimes Eric Guiry Anders J Hansen Ardern Hulme-Beaman John Johnson Andrew Kitchen Aleksei K Kasparov Young-Mi Kwon Pavel A Nikolskiy Carlos Peraza Lope Aurelie Manin Terrance Martin Michael Meyer Kelsey Noack Myers Mark Omura Jean-Marie Rouillard Elena Y Pavlova Paul Sciulli Mikkel-Holger S Sinding Andrea Strakova Varvara V Ivanova Christopher Widga Eske Willerslev Vladimir V Pitulko Ian Barnes M Thomas P Gilbert Keith M Dobney Ripan S Malhi Elizabeth P Murchison Greger Larson Laurent AF Frantz 2381/12665498.v1 https://figshare.le.ac.uk/articles/journal_contribution/The_evolutionary_history_of_dogs_in_the_Americas/12665498 Dogs were present in the Americas before the arrival of European colonists, but the origin and fate of these precontact dogs are largely unknown. We sequenced 71 mitochondrial and 7 nuclear genomes from ancient North American and Siberian dogs from time frames spanning ~9000 years. Our analysis indicates that American dogs were not derived from North American wolves. Instead, American dogs form a monophyletic lineage that likely originated in Siberia and dispersed into the Americas alongside people. After the arrival of Europeans, native American dogs almost completely disappeared, leaving a minimal genetic legacy in modern dog populations. The closest detectable extant lineage to precontact American dogs is the canine transmissible venereal tumor, a contagious cancer clone derived from an individual dog that lived up to 8000 years ago. 2020-07-31 12:30:10 Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics ANALYSES REVEAL GENOME REVEALS DOMESTIC DOGS GRAY WOLVES ORIGIN ANCIENT POPULATION CANCER WORLD