HFIP Paper (OBC_Stuart) final.pdf (497.51 kB)
Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol
journal contribution
posted on 2019-05-14, 11:02 authored by Harsimran K. Minhas, William Riley, Alison M. Stuart, Martyna UrbonaiteHexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
History
Citation
Organic and Biomolecular Chemistry, 2018, 16, 7170-7173Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of ChemistryVersion
- AM (Accepted Manuscript)