Connecting the dots in Huntington's disease with protein interaction networks

2012-10-24T09:04:20Z (GMT) by Flaviano Giorgini Paul J. Muchowski
Analysis of protein-protein interaction networks is becoming important for inferring the function of uncharacterized proteins. A recent study using this approach has identified new proteins and interactions that might be involved in the pathogenesis of the neurodegenerative disorder Huntington's disease, including a GTPase-activating protein that co-localizes with protein aggregates in Huntington's disease patients.