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Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value.

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posted on 15.01.2020 by Armin Lak, Michael Okun, Morgane M Moss, Harsha Gurnani, Karolina Farrell, Miles J Wells, Charu Bai Reddy, Adam Kepecs, Kenneth D Harris, Matteo Carandini
Deciding between stimuli requires combining their learned value with one's sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection with reinforcement learning. In the model, the predicted value of the chosen option is the product of sensory confidence and learned value. We found precise correlates of this variable in the pre-outcome activity of midbrain dopamine neurons and of medial prefrontal cortical neurons. However, only the latter played a causal role: inactivating medial prefrontal cortex before outcome strengthened learning from the outcome. Dopamine neurons played a causal role only after outcome, when they encoded reward prediction errors graded by confidence, influencing subsequent choices. These results reveal neural signals that combine reward value with sensory confidence and guide subsequent learning.

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Citation

Lak et al., Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value, Neuron(2019), https://doi.org/10.1016/j.neuron.2019.11.018

Author affiliation

Centre for Systems Neuroscience, Department of Neuroscience, Psychology and Behaviour

Version

VoR (Version of Record)

Published in

Neuron

Publisher

Elsevier BV

issn

0896-6273

eissn

1097-4199

Acceptance date

11/11/2019

Copyright date

2019

Available date

16/12/2019

Publisher version

https://www.sciencedirect.com/science/article/pii/S0896627319309821

Spatial coverage

United States

Language

eng

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