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Engineered magnetoactive collagen hydrogels with tunable and predictable mechanical response.pdf (3.64 MB)

Engineered magnetoactive collagen hydrogels with tunable and predictable mechanical response

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journal contribution
posted on 2020-05-26, 13:51 authored by Savvas Karagiorgis, Alkiviadis Tsamis, Chrysovalantis Voutouri, Rodica Turcu, Sebastian Alin Porav, Vlad Socoliuc, Ladislau Vekas, Maria Louca, Triantafyllos Stylianopoulos, Vasileios Vavourakis, Theodora Krasia-Christoforou

In the present study, the synthesis of superparamagnetic collagen-based nanocomposite hydrogels with tunable swelling, mechanical and magnetic properties is reported. The fabrication strategy involved the preparation of pristine collagen type-I hydrogels followed by their immersion in highly stable aqueous solutions containing pre-formed double-layer oleic acid-coated hydrophilic magnetite nanoparticles (OA.OA.Fe3O4) at different concentrations, to interrogate nanoparticles' deposition within the 3D fibrous collagen matrix. Besides the investigation of the morphology, composition and magnetic properties of the produced materials, their mechanical properties were experimentally evaluated under confined compressive loading conditions while an exponential constitutive equation was employed to describe their mechanical response. Moreover, the deposition of the nanoparticles in the collagenous matrix was modeled mathematically with respect to the swelling of the gel and the effective stiffness of the matrix. The model recapitulated nanoparticle diffusion and deposition as well as hydrogel swelling, in terms of nanoparticles' size and concentration of OA.OA.Fe3O4 aqueous solution.

Funding

V. Socoliuc and L. Vekas acknowledge the financial support from the Romanian Academy –Timisoara Branch 2016-2020 Research Program and from a grant of the Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, project number PN-III-PI-1,2-PCCDI-2017-0871, contract c47PCCDI/2018. The aqueous magnetic fluid samples used in this work were prepared by Mrs. Florica Balanean (RA-TB). R. Turcu and S.A. Porav acknowledge the financial support from the Romanian Ministry of Research and Innovation, Core Programme, Project No 36N/2019 PN19-35 02 03.

History

Citation

Materials Science and Engineering: C Volume 114, September 2020, 111089

Published in

Materials Science and Engineering: C

Volume

114

Pagination

111089

Publisher

Elsevier BV

issn

0928-4931

Acceptance date

2020-05-08

Copyright date

2020

Language

en

Publisher version

https://www.sciencedirect.com/science/article/pii/S0928493120309140

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