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Skin Autofluorescence A Non-Invasive Marker of Advanced Glycation End Products Clinical Relevance and LimitationsBW.docx (101.75 kB)

Skin autofluorescence, a non-invasive marker of advanced glycation end products: clinical relevance and limitations.

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journal contribution
posted on 2020-03-30, 16:27 authored by C Da Moura Semedo, M Webb, H Waller, K Khunti, M Davies
Advanced glycation end products (AGEs) are protein-bound compounds derived from glycaemic and oxidative stress that contain fluorescent properties, which can be non-invasively measured as skin autofluorescence (SAF) by the AGE Reader. SAF has been demonstrated to be a biomarker of cumulative skin AGEs and potentially may be a better predictor for the development of chronic complications and mortality in diabetes than glycated haemoglobin A1c. However, there are several confounding factors that should be assessed prior to its broader application: these include presence of other fluorescent compounds in the skin that might be measured (eg, fluorophores), skin pigmentation and use of skin creams. The aim of this article is to provide a theoretical background of this newly developed method, evaluate its clinical relevance and discuss the potential confounding factors that need further analysis.

History

Citation

Postgrad Med J, 2017, 93 (1099), pp. 289-294

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Published in

Postgrad Med J

Volume

93

Issue

1099

Pagination

289-294

Publisher

BMJ Publishing Group for Fellowship of Postgraduate Medicine(FPM)

eissn

1469-0756

Acceptance date

2017-01-08

Copyright date

2017

Available date

2017-01-31

Publisher version

https://pmj.bmj.com/content/93/1099/289

Language

eng