1745-6215-15-371.pdf (1.3 MB)
The REFLO-STEMI trial comparing intracoronary adenosine, sodium nitroprusside and standard therapy for the attenuation of infarct size and microvascular obstruction during primary percutaneous coronary intervention: study protocol for a randomised controlled trial
journal contribution
posted on 2015-06-22, 08:23 authored by Sheraz A. Nazir, J. N. Khan, I. Z. Mahmoud, J. P. Greenwood, D. J. Blackman, V. Kunadian, M. Been, K. R. Abrams, R. Wilcox, A. A. Adgey, G. P. McCann, A. H. GershlickMicrovascular obstruction (MVO) secondary to ischaemic-reperfusion injury is an important but underappreciated determinant of short- and longer-term outcome following percutaneous coronary intervention (PCI) treatment of ST-elevation myocardial infarction (STEMI). Several small studies have demonstrated a reduction in the degree of MVO utilising a variety of vasoactive agents, with adenosine and sodium nitroprusside (SNP) being most evaluated. However, the evidence base remains weak as the trials have had variable endpoints, differing drug doses and delivery. As such, the results regarding benefit are conflicting.
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Trials, 2014, 15, p. 371Author affiliation
/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular SciencesVersion
- VoR (Version of Record)
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TrialsPublisher
BioMed Centraleissn
1745-6215Copyright date
2014Available date
2015-06-22Publisher DOI
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http://www.trialsjournal.com/content/15/1/371Notes
PMCID: PMC4189551Language
enAdministrator link
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AdenosineClinical ProtocolsCoronary AngiographyCoronary CirculationCoronary VesselsGreat BritainHumansMagnetic Resonance ImagingMicrocirculationMyocardial InfarctionMyocardial Perfusion ImagingNitroprussideNo-Reflow PhenomenonPercutaneous Coronary InterventionProspective StudiesReperfusion InjuryResearch DesignTime FactorsTreatment OutcomeVasodilator Agents
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