[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma..pdf (295.5 kB)
[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma.
journal contribution
posted on 2016-01-13, 11:00 authored by David Sweeney, Fay Hollins, Edith Gomez, Ruth Mary Saunders, R.A. John Challiss, Christopher E. BrightlingThe cause of airway smooth muscle (ASM) hypercontractility in asthma is not fully understood. The relationship of spontaneous intracellular calcium oscillation frequency in ASM to asthma severity was investigated. Oscillations were increased in subjects with impaired lung function abolished by extracellular calcium removal, attenuated by caffeine and unaffected by verapamil or nitrendipine. Whether modulation of increased spontaneous intracellular calcium oscillations in ASM from patients with impaired lung function represents a therapeutic target warrants further investigation.
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Citation
Respirology, 2014, 19 (5), pp. 763-766Author affiliation
/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and InflammationVersion
- VoR (Version of Record)
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RespirologyPublisher
Wiley for Asian Pacific Society of Respirologyissn
1323-7799eissn
1440-1843Copyright date
2014Available date
2016-01-13Publisher DOI
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http://onlinelibrary.wiley.com/doi/10.1111/resp.12318/abstractLanguage
enAdministrator link
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Keywords
airway hyperresponsivenessairway smooth muscleasthmacalciumoscillationsAdultAgedAsthmaBiopsyCaffeineCalcium SignalingCase-Control StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedMuscle, SmoothNitrendipinePulmonary Disease, Chronic ObstructiveRespiratory MusclesSeverity of Illness IndexVerapamilVital Capacity
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