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Association between IL-1RN VNTR polymorphism and head and neck cancer in Indonesian population

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conference contribution
posted on 12.02.2019, 15:21 by AV Rudijono, AW Suhartono, YH Midoen, Christopher Talbot, EI Auerkari
The interleukin-1 receptor antagonist (IL-1RN) is a natural antagonist of IL-1 receptors, and its 86-bp variable number tandem repeat (VNTR) polymorphism within intron 2 has been associated with the development of several cancers. This study aimed to evaluate the IL-1RN polymorphism for its potential association with head and neck cancer in Indonesia population. Polymerase chain reaction analysis was performed on stored blood-derived DNA samples from 110 control participants and 90 patients with head and neck cancer for the IL-1RN VNTR polymorphism. Chi-square and odds ratio were used for the statistical analysis. This study showed no significant difference in the frequencies of genotypes or alleles in either the control or the cancer groups. However, a larger sample size could reveal a more significant difference between the groups. The IL-1RN VNTR polymorphism was not associated with head and neck cancer in the studied Indonesian population.

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Citation

Journal of Physics: Conference Series 1073, 2018, 032063

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Source

The 2nd Physics and Technologies in Medicine and Dentistry Symposium 18 July 2018, West Java

Version

VoR (Version of Record)

Published in

Journal of Physics: Conference Series 1073

Publisher

IOP Publishing

issn

1742-6588

eissn

1742-6596

Copyright date

2018

Available date

12/02/2019

Publisher version

https://iopscience.iop.org/article/10.1088/1742-6596/1073/3/032063/meta

Language

en

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