2016 - CinC - Almeida et al - Inconsistencies in persAF ablation outcomes targeting CFAEs - Manuscript - V6.pdf (447.08 kB)
Download file

Contributing Factors Concerning Inconsistencies in Persistent Atrial Fibrillation Ablation Outcomes

Download (447.08 kB)
conference contribution
posted on 14.11.2016, 11:14 by Tiago P. Almeida, Gavin S. Chu, Xin Li, J. L. Salinet, Nawshin Dastagir, Michael J. Bell, F. J. Vanheusden, Jiun H. Tuan, Peter J . Stafford, G. A. Ng, Fernando S. Schlindwein
In the present work, we investigated current methods for complex fractionated atrial electrogram (CFAE) classification during persistent atrial fibrillation (persAF). Potential contributing factors concerning the low reproducibility of CFAE-guided ablation outcomes in persAF therapy have been explored, such as inconsistencies in automated CFAE classification performed by different systems, the co-existence of different types of atrial electrograms (AEGs), and insufficient AEG duration for CFAE detection. First, we show that CFAE classification may vary for the same individual, depending on the system being used and settings being applied. Revised thresholds are suggested for the indices calculated by each system to minimize the differences in CFAE detection performed independently by them. Second, our results show that some AEGs are affected by stepwise persAF ablation, while others remain unaffected by it. Different types of AEGs might correlate with distinct underlying persAF mechanisms. Single descriptors measured from the AEGs, such as sample entropy and dominant frequency, were not able to discriminate the different types of AEGs individually, but multivariate analysis using multiple descriptors measured from the AEGs can effectively discriminate the different types of AEGs. Finally, we show that AEG duration of 2.5 s – as currently used by some systems – might not be sufficient to measure CFAEs consistently.

History

Citation

Computing in Cardiology 2016, 43, pp. 689-692.

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Source

CinC 2016, Computing in Cardiology, Canada

Version

VoR (Version of Record)

Published in

Computing in Cardiology 2016

Publisher

IEEE

issn

2325-8861

eissn

2325-887X

Copyright date

2016

Available date

14/03/2017

Publisher version

http://ieeexplore.ieee.org/document/7868836/

Temporal coverage: start date

11/09/2016

Temporal coverage: end date

14/09/2016

Language

en

Usage metrics

Categories

Keywords

Exports