nd139_CinC'16_final.pdf (271.83 kB)
Download file

Dynamic Behavior of Rotors during Human Persistent Atrial Fibrillation as observed using Non-Contact Mapping

Download (271.83 kB)
conference contribution
posted on 14.11.2016, 11:19 by Nawshin Dastagir, Tiago P. Almeida, Xin Li, F. J. Vanheusden, Gavin S . Chu, Peter J. Stafford, G. André Ng, Fernando S. Schlindwein
Rotors have been related to atrial fibrillation (AF) maintenance. We analyzed the behavior of rotors in persistent AF (persAF) utilizing a novel non-contact methodology and compared this to real time dominant frequency (DF) analysis. 2048 noncontact virtual unipolar atrial electrograms (VEGMs) were collected simultaneously (EnSite Array, St. Jude Medical) from 10 persAF patients (duration: 34 ± 25 months) undergoing left atrial (LA) ablation. After QRST-removal, FFT was used to identify the global DF of the LA (range 4 - 10 Hz; 1 s time-window; 50 % overlap; highest DF (HDF) (DF -0.25 Hz); up to 20 s/patient). The organization index (OI) was measured and phase was found via Hilbert-transform. Phase singularities (PSs) were tracked and were categorized according to their lifespan into short (lifespan <100 ms) and long lived (rotors) (lifespan ≥100 ms). A total of 4578 PSs were tracked. 5.05 % (IQR: 2.75 ~ 30.25 %) of the tracked PSs were long-lived and were observed in 11 % (IQR: 2.75 ~ 17.5 %) of the windows. The windows with rotors showed significantly higher HDF (mean ± SD, 8.0 ± 0.43 Hz vs 7.71 ± 0.50 Hz, p< 0.0001) and lower OI (0.76 ± 0.04 vs 0.79 ± 0.03, p< 0.0001) when compared with the short-lived PSs windows. During persAF, the LA showed distinct behaviors as characterized by rotors. Often, no rotors were observed during sustained AF and, when present, the rotors continually switched between organized and disorganized behaviors. Long-lived rotors correlated with higher atrial rates. Our results suggest that rotors are not the sole perpetuating mechanism in persAF.

Funding

The work described in this paper is part of the research portfolio supported by the Leicester National Institute for Health Research (NIHR) Biomedical Research Unit (BRU) in Cardiovascular Disease, UK. TPA and JLS have received research grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. The authors would like to acknowledge the financial support from the (NIHR) Leicester Cardiovascular BRU and CNPq.

History

Citation

Computing in Cardiology 2016, 43, pp. 241-244

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Source

CinC 2016, Computing in Cardiology 2016, Canada

Version

VoR (Version of Record)

Published in

Computing in Cardiology 2016

Publisher

IEEE

issn

2325-8861

eissn

2325-887X

Copyright date

2016

Available date

14/03/2017

Publisher version

http://ieeexplore.ieee.org/document/7868724/

Temporal coverage: start date

11/09/2016

Temporal coverage: end date

14/09/2016

Language

en

Usage metrics

Categories

Keywords

Exports