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Galactose deficient IgA1 (GD-IgA1) in skin and serum from patients with skin-limited and systemic IgA Vasculitis.

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conference contribution
posted on 25.04.2019, 14:56 by M Neufeld, K Molyneux, KI Pappelbaum, S Mayer-Hain, C von Hodenberg, J Ehrchen, J Barratt, Y Suzuki, C Sunderkötter
BACKGROUND: IgA-vasculitis (IgAV) encompasses a systemic form involving kidneys, gut, skin or joints, and a skin-limited form. One characteristic feature of systemic IgAV is deposition of galactose-deficient IgA1 (GD-IgA1) in kidneys (as in IgA-nephropathy). The relevance of GD-IgA1 for cutaneous vasculitis is unknown. OBJECTIVE: We investigated if GD-IgA1 is deposited perivascularly in systemic and also skin-limited IgAV, and if its serum levels differ between both forms. METHODS: In a case control study, deposition of GD-IgA1 was analysed immunohistochemically by KM55-antibody in skin biopsies from 12 patients with skin-limited and 4 with systemic IgAV. GD-IgA1-levels were compared by ELISA in sera from 15 patients each with skin-limited and systemic IgAV and from 11 healthy subjects. RESULTS: All biopsies from systemic, but also from skin-limited IgAV revealed perivascular GD-IgA1-deposition. The average GD-IgA1-level in serum was significantly higher in systemic than in skin-limited IgAV, despite overlap between both groups. LIMITATIONS: Although high GD-IgA1-levels may be predictive of systemic IgAV, patient numbers were too low to determine cut-off values for systemic versus skin-limited IgAV. CONCLUSION: While perivascular GD-IgA1-deposition is a prerequisite for systemic and skin-limited IgAV, high GD-IgA1-levels in some patients with systemic IgAV suggest a dose-dependent effect of GD-IgA1 in IgAV.

History

Citation

Journal of The American Academy of Dermatology, 2019

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Source

United States

Version

AM (Accepted Manuscript)

Published in

Journal of The American Academy of Dermatology

Publisher

Elsevier for American Academy of Dermatology, Mosby

eissn

1097-6787

Acceptance date

10/03/2019

Copyright date

2019

Publisher version

https://www.sciencedirect.com/science/article/pii/S0190962219304438?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en