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Human exome-chip meta-analysis identifies novel genetic loci associated with smoking behaviour

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conference contribution
posted on 08.11.2016, 09:30 by A. Mesut Erzurumluoglu, Carl A. Melbourne, Victoria E. Jackson, Louise V. Wain, Martin D. Tobin, Consortium for the Genetics of Smoking Behaviour
Smoking is a major risk factor for many diseases, including common respiratory disorders such as chronic obstructive pulmonary disease. Previous GWASs have been successful in identifying 13 common SNPs associated with smoking behaviour. Meta-analysing summary data from up to 33 cohorts, we have carried out an association study between the SNPs found on the exome-chip (n ≈250k SNPs), which predominantly assays rare putatively functional variants, and four traits: Smoking Initiation (n≈80k), Smoking Cessation (n≈41.5k), Cigarettes Per Day (n≈26.5k) and Pack Years (n≈33k). In addition to identifying previously reported signals with regards to smoking behaviour, we have identified SNPs in 5 novel regions, including a rare variant on chromosome 16 (MAF=0.01%). The previously identified SNPs fall within CHRNA5 (rs16969968, missense), CHRNA3 (rs938682, intronic) and IREB2 (rs13180, synonymous) – which are all located at the 15q25 locus. We are currently initiating follow-up studies; and if replicated, the novel loci identified in this study will facilitate understanding the genetic aetiology of smoking behaviour and may lead to identification of drug targets of potential relevance to smoking cessation.

History

Citation

Target Validation Using Genomics and Informatics, Heidelberg, Germany

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Source

Target Validation Using Genomics and Informatics, Heidelberg, Germany

Version

AO (Author's Original)

Published in

Target Validation Using Genomics and Informatics

Acceptance date

03/11/2016

Available date

08/11/2016

Publisher version

http://www.embl.de/training/events/2016/TAR16-01/

Temporal coverage: start date

04/12/2016

Temporal coverage: end date

06/12/2016

Language

en

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