Auerkari_2018_J._Phys.%3A_Conf._Ser._1025_012060.pdf (645.66 kB)
Download file

Polymorphism of Cyplal (T6235C) is not a significant risk factor of osteoporosis in postmenopausal Indonesian woman

Download (645.66 kB)
conference contribution
posted on 12.02.2019, 15:45 by E Auerkari, LW Budhy, R Kiranahayu, NZ Djamal, LS Kusdhany, TBW Rahardjo, Christopher Talbot
Osteoporosis is an increasingly common disease resulting in reduced bone mineral density (BMD) and elevated likelihood of bone fracture, and particularly affected are postmenopausal women with additional risk factors including genetic predisposition. The CYP1A1, is one of the candidate genes that have been suggested to be associated with the pathogenesis of osteoporosis. This work aimed to evaluate the distribution of a selected polymorphism of this gene (T6235C) with respect to the BMD status in postmenopausal Indonesian women. The results show that osteoporosis is associated with age and menopause, as expected, but not with the tested polymorphism of CYP1A1 in the Indonesian sample population. It is suggested that other P450 cytochrome enzymes and their polymorphisms could provide more significant indicators of the future health of postmenopausal women.

History

Citation

Journal of Physics: Conference Series, 1025, 2018, 012060

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Source

The 7th International Seminar on New Paradigm and Innovation on Natural Science and Its Application 17 October 2017, Semarang, Indonesia

Version

VoR (Version of Record)

Published in

Journal of Physics: Conference Series

Publisher

IOP Publishing

issn

1742-6588

eissn

1742-6596

Copyright date

2018

Available date

12/02/2019

Publisher version

https://iopscience.iop.org/article/10.1088/1742-6596/1025/1/012060/meta

Editors

Warsito, B;Putro, SP;Khumaeni, A

Temporal coverage: start date

17/10/2017

Language

en