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Spatiotemporal Behaviour of High Dominant Frequency during Persistent Atrial Fibrillation

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conference contribution
posted on 16.02.2015, 13:10 by Nawshin Dastagir, João Salinet, Frederique J. Vanheusden, Tiago P. Almeida, Xin Li, Gavin S. Chu, G. André Ng, Fernando S. Schlindwein
Atrial electrograms (EGMs) with high dominant frequency (DF) are believed to represent atrial substrates with periodic activation responsible for the maintenance of persistent atrial fibrillation (persAF). This study aimed to assess the DF spatiotemporal behavior using high density noncontact mapping in persAF. For 8 patients undergoing left atrial (LA) persAF ablation, 2048 noncontact virtual unipolar EGMs were simultaneously collected and after the removal of ventricular far-field activity, Fourier based spectral analysis was used to identify DF on each EGM. Atrial areas with the highest DF (HDF, DF ± 0.25 Hz) were delimited in each frame for all EGMs, creating HDF ‘clouds’. Cumulative HDF clouds found at each frame were counted in the 3-D LA representation. To further assess the temporal stability of the cloud, the number of EGMs not hosting any HDF was determined for each window over time. The results show the number of occurrences of HDF clouds in the LA. The temporal behavior was analyzed by counting the number of positions on the 3-D representation of the LA not visited by HDF along time. Our results show HDF in persAF is not temporally stable and spatial distribution throughout the atria suggests the existence of driver regions with very rapid and regular activity maintaining AF. Therefore mapping the cumulative HDF might be an interesting strategy for ablation.

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Citation

Spatiotemporal Behaviour of High Dominant Frequency during Persistent Atrial Fibrillation 2014 presented at Computing in Cardiology, Cambridge, Mass. USA

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Source

Computing in Cardiology, Cambridge, Mass. USA

Version

AM (Accepted Manuscript)

Published in

Spatiotemporal Behaviour of High Dominant Frequency during Persistent Atrial Fibrillation 2014 presented at Computing in Cardiology

issn

2325-8861

isbn

978-1-4799-4346-3

Available date

16/02/2015

Publisher version

http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7043127&tag=1

Editors

Murray, A.

Temporal coverage: start date

07/09/2014

Temporal coverage: end date

10/09/2014

Language

en

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