191122 MJD comments 5039 Buse Consensus Report Update proofs (1).pdf (1.34 MB)
Download file

2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Download (1.34 MB)
journal contribution
posted on 21.02.2020, 16:07 by John B Buse, Deborah J Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A D'Alessio, Melanie J Davies
The American Diabetes Association and the European Association for the Study of Diabetes have briefly updated their 2018 recommendations on management of hyperglycemia, based on important research findings from large cardiovascular outcomes trials published in 2019. Important changes include: 1) the decision to treat high-risk individuals with a glucagon-like peptide 1 (GLP-1) receptor agonist or sodium-glucose cotransporter 2 (SGLT2) inhibitor to reduce major adverse cardiovascular events (MACE), hospitalization for heart failure (hHF), cardiovascular death, or chronic kidney disease (CKD) progression should be considered independently of baseline HbA1c or individualized HbA1c target; 2) GLP-1 receptor agonists can also be considered in patients with type 2 diabetes without established cardiovascular disease (CVD) but with the presence of specific indicators of high risk; and 3) SGLT2 inhibitors are recommended in patients with type 2 diabetes and heart failure, particularly those with heart failure with reduced ejection fraction, to reduce hHF, MACE, and CVD death, as well as in patients with type 2 diabetes with CKD (estimated glomerular filtration rate 30 to ≤60 mL min-1 [1.73 m]-2 or urinary albumin-to-creatinine ratio >30 mg/g, particularly >300 mg/g) to prevent the progression of CKD, hHF, MACE, and cardiovascular death.

History

Citation

Diabetes Care 2019 Dec; dci190066. https://doi.org/10.2337/dci19-0066

Author affiliation

Diabetes Research Centre, University of Leicester

Version

AM (Accepted Manuscript)

Published in

Diabetes care

Pagination

dci190066 - dci190066

Publisher

American Diabetes Association

issn

0149-5992

eissn

1935-5548

Copyright date

2019

Publisher version

https://care.diabetesjournals.org/content/early/2019/12/18/dci19-0066

Notes

This article is being simultaneously published in Diabetologia (https://doi.org/10.1007/s00125-019-05039-w) and Diabetes Care (https://doi.org/10.2337/dci19-0066) by the European Association for the Study of Diabetes and the American Diabetes Association.

Spatial coverage

United States

Language

eng

Usage metrics

Categories

Exports