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ACE2, TMPRSS2 AND FURIN GENE EXPRESSION IN THE AIRWAYS OF PEOPLE WITH ASTHMA - IMPLICATIONS FOR COVID-19.

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posted on 09.06.2020, 09:22 by Peter Bradding, Matthew Richardson, Timothy SC Hinks, Peter H Howarth, David F Choy, Joseph R Arron, Sally E Wenzel, Salman Siddiqui
To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease. We have therefore explored ACE2 receptor mRNA expression, and co-factors for Sars-CoV-2 infectivity (TMPRSS2 and furin) in bronchial brushes and biopsies from people with asthma and healthy controls, and looked for relationships between asthma severity, Th2- and IL-17 dependent gene signatures, and clinical demographics (age, sex). We have looked at a cohort of 356 research participants from previously described studies. The only significant association was a positive correlation between ACE2 and IL-17-dependent gene expression, and an inverse correlation between ACE2 and Th2-cytokine-dependent gene expression. These data suggest that differences in ACE2, TMPRSS2 and furin epithelial and airway gene expression are unlikely to confer enhanced COVID-19 pneumonia risk in patients with asthma across all treatment intensities and severity.

Funding

This analysis was supported by the National Institute for Health Research (NIHR)Leicester Biomedical Research Centre (Respiratory theme) and the Wellcome Trust(088365/z/09/z)

History

Citation

Journal of Allergy and Clinical Immunology (2020)

Version

P (Proof)

Published in

Journal of allergy and clinical immunology

Publisher

Elsevier BV

issn

1097-6825

eissn

1097-6825

Acceptance date

14/04/2020

Copyright date

2020

Language

eng

Publisher version

https://www.sciencedirect.com/science/article/pii/S0091674920307302

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