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A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50

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journal contribution
posted on 07.10.2016, 10:48 by Kevser Sevim, Jingzhe Pan
Polyester microspheres are extensively studied for controlled release drug delivery devices, and many models have been developed to describe drug release from the bulk polymer. However, the interaction between drugs and polymers is ignored in most of the existing mathematical models. This paper presents a mechanistic model which captures the interplay between acidic drugs and bioresorbable polyesters. The model considers the autocatalytic effect on polymer degradation arising from carboxylic acid end groups of oligomers and drug molecules. Hence, the enhancing effect of acidic drug on the rate of degradation was fully considered. On the other hand the drug release from polyester microspheres is controlled by drug diffusion from polymer matrix. The drug diffusion coefficient depends strongly on the level of degradation of the polymer. This effect is also included in the model. It is shown that the model can effectively predict experimental data in the literature for both polymer degradation and drug release. Furthermore, the model is used to design different systems of microspheres which release drugs with either a zero order profile or burst followed by zero order release profile.

History

Citation

Molecular Pharmaceutics, 2016, 13 (8), pp. 2729-2735

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Version

AM (Accepted Manuscript)

Published in

Molecular Pharmaceutics

Publisher

American Chemical Society

issn

1543-8384

eissn

1543-8392

Acceptance date

11/07/2016

Copyright date

2016

Available date

11/07/2017

Publisher version

http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00313

Notes

Following the embargo period the above license applies.

Language

en