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A flexible parametric approach to examining spatial variation in relative survival.

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journal contribution
posted on 13.12.2016, 15:14 by S. M. Cramb, K. L. Mengersen, Paul C. Lambert, L. M. Ryan, P. D. Baade
Most of the few published models used to obtain small-area estimates of relative survival are based on a generalized linear model with piecewise constant hazards under a Bayesian formulation. Limitations of these models include the need to artificially split the time scale, restricted ability to include continuous covariates, and limited predictive capacity. Here, an alternative Bayesian approach is proposed: a spatial flexible parametric relative survival model. This overcomes previous limitations by combining the benefits of flexible parametric models: the smooth, well-fitting baseline hazard functions and predictive ability, with the Bayesian benefits of robust and reliable small-area estimates. Both spatially structured and unstructured frailty components are included. Spatial smoothing is conducted using the intrinsic conditional autoregressive prior. The model was applied to breast, colorectal, and lung cancer data from the Queensland Cancer Registry across 478 geographical areas. Advantages of this approach include the ease of including more realistic complexity, the feasibility of using individual-level input data, and the capacity to conduct overall, cause-specific, and relative survival analysis within the same framework. Spatial flexible parametric survival models have great potential for exploring small-area survival inequalities, and we hope to stimulate further use of these models within wider contexts.

Funding

PDB was supported by an Australian National Health and Medical Research Council Career Development Fellowship (#1005334). KLM acknowledges support from the Cooperative Research Centre for Spatial Information, whose activities are funded by the Australian Commonwealth's Cooperative Research Centres Programme. LMR and KLM acknowledge support from the ARC Centre of Excellence in Mathematical and Statistical Frontiers.

History

Citation

Statistics in Medicine, 2016, 35 (29), pp. 5448-5463

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Version

AM (Accepted Manuscript)

Published in

Statistics in Medicine

Publisher

Wiley

issn

0277-6715

eissn

1097-0258

Acceptance date

12/07/2016

Available date

08/08/2017

Publisher version

http://onlinelibrary.wiley.com/doi/10.1002/sim.7071/abstract

Language

en