journal contribution posted on 14.06.2019, 14:41 by C. Lu, K. Laws, A. Eskandari, K. Suntharalingam
Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.
K. S. is supported by a Leverhulme Early Career Fellowship (ECF-2014-178). K. L. and A. E. are supported by a King's College London GTS-PhD Studentship and Faculty Graduate School International Studentship, respectively. C. L. thanks the National Natural Science Foundation of China (Grant No. 21401078) for financial support. We are grateful to Prof. Robert Weinberg (Whitehead Institute, MIT) for providing the cell lines used in this study.
CitationDalton Transactions, 2017, 46 (38), pp. 12785-12789
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
VersionAM (Accepted Manuscript)
Published inDalton Transactions
PublisherRoyal Society of Chemistry