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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.

journal contribution
posted on 14.06.2019, 14:41 by C. Lu, K. Laws, A. Eskandari, K. Suntharalingam
Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

Funding

K. S. is supported by a Leverhulme Early Career Fellowship (ECF-2014-178). K. L. and A. E. are supported by a King's College London GTS-PhD Studentship and Faculty Graduate School International Studentship, respectively. C. L. thanks the National Natural Science Foundation of China (Grant No. 21401078) for financial support. We are grateful to Prof. Robert Weinberg (Whitehead Institute, MIT) for providing the cell lines used in this study.

History

Citation

Dalton Transactions, 2017, 46 (38), pp. 12785-12789

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry

Version

AM (Accepted Manuscript)

Published in

Dalton Transactions

Publisher

Royal Society of Chemistry

eissn

1477-9234

Acceptance date

03/09/2017

Copyright date

2017

Available date

14/06/2019

Publisher version

https://pubs.rsc.org/en/content/articlelanding/2017/DT/C7DT02789C#!divAbstract

Language

en