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A study of the temperature dependence of bienzyme systems and enzymatic chains

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journal contribution
posted on 27.05.2016, 14:50 by N. V. Kotov, R. E. Baker, D. A. Dawidov, K. V. Platov, Najil V. Valeyev, A. I. Skorinkin, P. K. Maini
It is known that most enzyme-facilitated reactions are highly temperature dependent processes. In general, the temperature coefficient, Q10, of a simple reaction reaches 2.0-3.0. Nevertheless, some enzyme-controlled processes have much lower Q10 (about 1.0), which implies that the process is almost temperature independent, even if individual reactions involved in the process are themselves highly temperature dependent. In this work, we investigate a possible mechanism for this apparent temperature compensation: simple mathematical models are used to study how varying types of enzyme reactions are affected by temperature. We show that some bienzyme-controlled processes may be almost temperature independent if the modules involved in the reaction have similar temperature dependencies, even if individually, these modules are strongly temperature dependent. Further, we show that in non-reversible enzyme chains the stationary concentrations of metabolites are dependent only on the relationship between the temperature dependencies of the first and last modules, whilst in reversible reactions, there is a dependence on every module. Our findings suggest a mechanism by which the metabolic processes taking place within living organisms may be regulated, despite strong variation in temperature.

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Citation

Computational and Mathematical Methods in Medicine, 2007, 8 (2), pp. 93-112

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Version

VoR (Version of Record)

Published in

Computational and Mathematical Methods in Medicine

Publisher

Hindawi Publishing Corporation

issn

1748-670X

eissn

1748-6718

Acceptance date

08/03/2007

Copyright date

2007

Available date

27/05/2016

Publisher version

http://www.hindawi.com/journals/cmmm/2007/405154/abs/

Language

en

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