Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
CitationOrganic and Biomolecular Chemistry, 2018, 16, 7170-7173
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistry
VersionAM (Accepted Manuscript)
Published inOrganic and Biomolecular Chemistry
PublisherRoyal Society of Chemistry
NotesElectronic supplementary information (ESI) available: Experimental procedures, NMR spectra. CCDC 1859674–1859676. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8ob02236d;The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.