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Age-dependent effects of protein restriction on dopamine release

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journal contribution
posted on 29.07.2021, 09:58 by F Naneix, KZ Peters, AMJ Young, JE McCutcheon
Despite the essential role of protein intake for health and development, very little is known about the impact of protein restriction on neurobiological functions, especially at different stages of the lifespan. The dopamine system is a central actor in the integration of food-related processes and is influenced by physiological state and food-related signals. Moreover, it is highly sensitive to dietary effects during early life periods such as adolescence due to its late maturation. In the present study, we investigated the impact of protein restriction either during adolescence or adulthood on the function of the mesolimbic (nucleus accumbens) and nigrostriatal (dorsal striatum) dopamine pathways using fast-scan cyclic voltammetry in rat brain slices. In the nucleus accumbens, protein restriction in adults increased dopamine release in response to low and high frequency trains of stimulation (1–20 Hz). By contrast, protein restriction during adolescence decreased nucleus accumbens dopamine release. In the dorsal striatum, protein restriction at adulthood has no impact on dopamine release but the same diet during adolescence induced a frequency-dependent increases in stimulated dopamine release. Taken together, our results highlight the sensitivity of the different dopamine pathways to the effect of protein restriction, as well as their vulnerability to deleterious diet effects at different life stages.

Funding

This work was supported by the Biotechnology and Biological Sciences Research Council [grant #BB/M007391/1 to JEM], the European Commission [grant #GA 631404 to JEM], The Leverhulme Trust [grant #RPG-2017-417 to JEM] and the Tromsø Research Foundation [grant #19-SG-JMcC to JEM)

History

Citation

Naneix, F., Peters, K.Z., Young, A.M.J. et al. Age-dependent effects of protein restriction on dopamine release. Neuropsychopharmacol. 46, 394–403 (2021). https://doi.org/10.1038/s41386-020-0783-z

Author affiliation

Department of Neuroscience

Version

VoR (Version of Record)

Published in

Neuropsychopharmacology

Volume

46

Pagination

394–403

Publisher

Springer Nature for American College of Neuropsychopharmacology (ACNP)

issn

0893-133X

eissn

1740-634X

Acceptance date

21/07/2020

Copyright date

2020

Available date

29/07/2021

Spatial coverage

England

Language

English