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Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study.

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journal contribution
posted on 26.01.2016, 16:47 by Lucy Marshall, Caroline S. Beardsmore, Anina M. Pescatore, Claudia E. Kuehni, Erol A. Gaillard
Preschool wheezing affects one-third of all children growing up in the UK [1]. It varies in clinical presentation and severity, and there is evidence to suggest the co-existence of different wheeze phenotypes [2], some of which have been associated with adult asthma and chronic obstructive pulmonary disease [3]. Using data from the Leicester Respiratory Cohort studies [4], we have previously applied objective data-driven methods to distinguish three distinct preschool wheeze phenotypes: “atopic” and “non-atopic” persistent wheeze (PW) and transient viral wheeze (TVW) [5]. In children with PW, attacks of wheeze with and without colds were observed both at preschool age (0–5 years) and when followed-up at early school-age (4–8 years). Children with TVW, triggered predominantly by colds, had symptoms at age 0–5 years but not at age 4–8 years. Prognosis 5 years later (aged 8–13 years) was markedly better in children with TVW compared to the two PW phenotypes [6].

History

Citation

European Respiratory Journal, 2015, 46 (5), pp. 1486-1489

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

European Respiratory Journal

Publisher

European Respiratory Society

issn

0903-1936

eissn

1399-3003

Copyright date

2015

Available date

01/05/2017

Publisher version

http://erj.ersjournals.com/content/46/5/1486

Language

en

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