Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.pdf (1.64 MB)
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Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging.

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posted on 18.10.2019, 14:57 by X Cui, S Belo, D Krüger, Y Yan, RTM de Rosales, M Jauregui-Osoro, H Ye, S Su, D Mathe, N Kovács, I Horváth, M Semjeni, K Sunassee, K Szigeti, MA Green, PJ Blower
Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)3 layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [(18)F]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for (18)F-fluoride and 100% for (64)Cu-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)3 layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)3 coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of (18)F from NPs, but no sign of efflux of (64)Cu.


Authors thank Drs Alice Warley and Gama Vizcay, at Centre for Ultrastructural Imaging, King's College London for TEM, and Mr Andrew Cakebread at King's College for ICP-MS measurements. RTMR and DM would like to thank EU COST action TD1007 on PET-MRI. The help of László Papp, Sándor Hóbor and Gábor Németh from Mediso is kindly acknowledged. This research was supported by the Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under grant number WT088641/Z/09/Z, and the King's College London and UCL Comprehensive Cancer Imaging Centre funded by the CRUK (C1519/A10331) and EPSRC in association with the MRC and DoH (WT088641/Z/09/Z) (England), and by the National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London. PET and SPECT scanning equipment at KCL was funded by an equipment grant from the Wellcome Trust. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.



Biomaterials, 2014, 35 (22), pp. 5840-5846

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