Aminergic Signaling Controls Ovarian Dormancy in Drosophila.pdf (6.87 MB)
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Aminergic Signaling Controls Ovarian Dormancy in Drosophila.

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posted on 23.04.2018, 11:10 by Gabriele Andreatta, Charalambos P. Kyriacou, Thomas Flatt, Rodolfo Costa
In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay environmental cues to the endocrine system in order to induce dormancy remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling in Drosophila melanogaster. We find that both serotonin and dopamine enhance adult ovarian dormancy, while the downregulation of their respective signaling pathways in endocrine cells or tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. In contrast, octopamine signaling antagonizes dormancy. Our findings enhance our understanding of the ability of organisms to cope with unfavorable environments and illuminate some of the relevant signaling pathways.

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Citation

Scientific Reports, 2018, 8, article 2030

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Genetics and Genome Biology

Version

VoR (Version of Record)

Published in

Scientific Reports

Publisher

Nature Publishing Group

eissn

2045-2322

Acceptance date

16/01/2018

Copyright date

2018

Available date

23/04/2018

Publisher version

https://www.nature.com/articles/s41598-018-20407-z

Language

en

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