Wilkinson final approved version 2018 J Ren Nutr.pdf (490.83 kB)
Download file

Anthropometry-based Equations to Estimate Body Composition: A Suitable Alternative in Renal Transplant Recipients and Patients With Nondialysis Dependent Kidney Disease?

Download (490.83 kB)
journal contribution
posted on 04.06.2018, 13:49 by Thomas J. Wilkinson, Danielle Richler-Potts, Daniel G. D. Nixon, Jill Neale, Alice C. Smith
Objective Chronic kidney disease (CKD) patients and renal transplant recipients (RTRs) are characterized by aberrant body composition such as muscle wasting and obesity. It is still unknown which is the most accurate method to estimate body composition in CKD. We investigated the validity of the Hume equation and bioelectrical impedance analysis (BIA) as an estimate of body composition against dual-energy X-ray absorptiometry (DXA) in a cohort of nondialysis dependent (NDD)-CKD and RTRs. Design and methods This was a cross-sectional study with agreement analysis of different assessments of body composition conducted in 61 patients (35 RTRs and 26 NDD-CKD) in a secondary care hospital setting in the UK. Body composition (lean mass [LM], fat mass [FM], and body fat% [BF%]) was assessed using multifrequency BIA and DXA, and estimated using the Hume formula. Method agreement was assessed by intraclass correlation coefficient (ICC), regression, and plotted by Bland and Altman analysis. Results Both BIA and the Hume formula were able to accurately estimate body composition against DXA. In both groups, the BIA overestimated LM (1.7-2.1 kg, ICC .980-.984) and underestimated FM (1.3-2.1 kg, ICC .967-.972) and BF% (3.1-3.8%, ICC .927-.954). The Hume formula also overestimated LM (3.5-3.6 kg, ICC .950-.960) and underestimated BF% (1.9-2.1%, ICC .808-.859). Hume-derived FM was almost identical to DXA in both groups (−0.3 to 0.1 kg, ICC .947-.960). Conclusion Our results demonstrate, in RTR and NDD-CKD patients, that the Hume formula, whose estimation of body composition is based only upon height, body mass, age, and sex, may reliably predict the same parameters obtained by DXA. In addition, BIA also provided similar estimates versus DXA. Thus, the Hume formula and BIA could provide simple and inexpensive means to estimate body composition in renal disease.

Funding

The authors gratefully acknowledge the Stoneygate Trust whom part-funded this work. The research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC).

History

Citation

Journal of Renal Nutrition, 2018

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

Journal of Renal Nutrition

Publisher

Elsevier for Council on Renal Nutrition of the National Kidney Foundation, International Society of Renal Nutrition and Metabolism

issn

1051-2276

eissn

1532-8503

Copyright date

2018

Available date

24/05/2019

Publisher version

https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1051227618300815?returnurl=https://linkinghub.elsevier.com/retrieve/pii/S1051227618300815?showall=true&referrer=

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en