AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.pdf (1.76 MB)
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AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials

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journal contribution
posted on 27.04.2018, 10:49 by Graham M. Wheeler, Michael J. Sweeting, Adrian P. Mander
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.

History

Citation

PLoS One, 2016, 11 (7), e0159026

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

VoR (Version of Record)

Published in

PLoS One

Publisher

Public Library of Science

eissn

1932-6203

Acceptance date

24/06/2016

Copyright date

2016

Available date

27/04/2018

Publisher version

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159026

Language

en