Masukume G, McCarthy FP, Baker PN, et al. Association between caesarean section delivery and obesity in childhood - a longitudinal cohort study in Ireland. BMJ Open 2019;9-e025051..pdf (552.78 kB)
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Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland.

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posted on 18.06.2019, 10:19 by G Masukume, FP McCarthy, PN Baker, LC Kenny, SM Morton, DM Murray, JO Hourihane, AS Khashan
OBJECTIVES: To investigate the association between caesarean section (CS) birth and body fat percentage (BF%), body mass index (BMI) and being overweight or obese in early childhood. DESIGN: Prospective longitudinal cohort study. SETTING: Babies After Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints cohort. PARTICIPANTS: Infants born to mothers recruited from the Screening for Pregnancy Endpoints study, Cork University Maternity Hospital between November 2007 and February 2011. OUTCOME MEASURE: Overweight or obese defined according to the International Obesity Task Force criteria. RESULTS: Of the 1305 infants, 362 (27.8%) were delivered by CS. On regression analysis, BF% at 2 months did not differ significantly by delivery mode. Infants born by CS had a higher mean BMI at 6 months compared with those born vaginally (adjusted mean difference=0.24; 95% CI 0.06 to 0.41, p value=0.009). At 2 years, no difference was seen across the exposure groups in the risk of being overweight or obese. At 5 years, the association between prelabour CS and the risk of overweight or obesity was not statistically significant (adjusted relative risk ratio, aRRR=1.37; 95% CI 0.69 to 2.69) and the association remained statistically nonsignificant when children who were macrosomic at birth were excluded from the model (aRRR=0.86; 95% CI 0.36 to 2.08). CONCLUSION: At 6 months of age, children born by CS had a significantly higher BMI but this did not persist into future childhood. There was no evidence to support an association between mode of delivery and long-term risk of obesity in the child.

Funding

SCOPE Ireland was supported by the Health Research Board, Ireland (CSA 2007/2). The BASELINE cohort was funded by the National Children’s Research Centre, Dublin, Ireland, and the Food Standards Agency of the United Kingdom (grant no. TO7060). GM is supported by the Irish Centre for Fetal and Neonatal Translational Research (INFANT) (grant no. 12/RC/2272). The other authors report no support relevant to this article.

History

Citation

BMJ Open 2019;9:e025051

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES

Version

VoR (Version of Record)

Published in

BMJ Open 2019;9:e025051

Publisher

BMJ Publishing Group

eissn

2044-6055

Acceptance date

13/11/2018

Copyright date

2019

Available date

18/06/2019

Publisher version

https://bmjopen.bmj.com/content/9/3/e025051

Notes

Data may be accessed by request from the Babies After SCOPE: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints (BASELINE) study. Contact details are available on the study website http://www.baselinestudy.net/.

Language

en

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