Paper NMCD FZ.pdf (764.31 kB)
Download file

Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: a prospective study

Download (764.31 kB)
journal contribution
posted on 05.06.2015, 09:29 by Francesco Zaccardi, D. R. Webb, P. Carter, D. Pitocco, Kamlesh Khunti, M. J. Davies, S. Kurl, J. A. Laukkanen
Background and aims: Previous prospective studies showing a positive association between serum calcium and incidence of type 2 diabetes mellitus (T2DM) have relied on total calcium or an indirect estimate of active, ionized calcium (iCa). We aimed to assess this relationship using a direct measurement of iCa. Methods and results: iCa and cardiometabolic risk factors were measured in a population-based sample of 2350 men without a known history of T2DM at baseline. Associations between iCa levels and incident cases of T2DM (self-reported, ascertained with a glucose tolerance test, or determined by record linkage to national registers) were estimated using Cox regression analyses adjusted for potential confounders. At baseline, mean (standard deviation) age was 53 (5) years and mean iCa 1.18 (0.05) mmol/L. During a median follow-up of 23.1 years, 140 new cases of T2DM were recorded. In a multivariable analysis adjusted for age, body mass index, systolic blood pressure, serum HDL-cholesterol, and family history of T2DM, there was no association comparing second (hazard ratio 0.84; 95% confidence interval 0.59–1.18), third (0.77; 0.52–1.14), or fourth (0.98; 0.69–1.39) vs first quartile of iCa (p for trend 0.538); further adjustment for C-reactive protein, physical activity level, and triglycerides did not change the estimates (p for trend 0.389). Conclusion: In this study, we did not find evidence of an association between direct measurement of active calcium and risk of T2DM. Further studies are needed to confirm our findings and define the relationship between factors influencing indirect calcium estimation and incident T2DM.

History

Citation

Nutrition Metabolism and Cardiovascular Diseases, 2015, 25 (6), pp 562–568

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine

Version

AM (Accepted Manuscript)

Published in

Nutrition Metabolism and Cardiovascular Diseases

Publisher

Elsevier

issn

0939-4753

eissn

1590-3729

Copyright date

2015

Available date

05/06/2015

Publisher version

http://www.sciencedirect.com/science/article/pii/S0939475315000563#

Language

en

Usage metrics

Categories

Keywords

Exports