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Association of walking pace and handgrip strength with all-cause, cardiovascular and cancer mortality: A UK Biobank observational study

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journal contribution
posted on 23.11.2017, 15:28 by Thomas E. Yates, Francesco Zaccardi, Nafeesa N. Dhalwani, Melanie J. Davies, Kishan Bakrania, Carlos A. Celis-Morales, Jason M. R. Gill, Paul W. Franks, Kamlesh Khunti
AIMS To quantify the association of self-reported walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality. METHODS AND RESULTS A total of 230 670 women and 190 057 men free from prevalent cancer and cardiovascular disease were included from UK Biobank. Usual walking pace was self-defined as slow, steady/average or brisk. Handgrip strength was assessed by dynamometer. Cox-proportional hazard models were adjusted for social deprivation, ethnicity, employment, medications, alcohol use, diet, physical activity, and television viewing time. Interaction terms investigated whether age, body mass index (BMI), and smoking status modified associations. Over 6.3 years, there were 8598 deaths, 1654 from cardiovascular disease and 4850 from cancer. Associations of walking pace with mortality were modified by BMI. In women, the hazard ratio (HR) for all-cause mortality in slow compared with fast walkers were 2.16 [95% confidence interval (CI): 1.68–2.77] and 1.31 (1.08–1.60) in the bottom and top BMI tertiles, respectively; corresponding HRs for men were 2.01 (1.68–2.41) and 1.41 (1.20–1.66). Hazard ratios for cardiovascular mortality remained above 1.7 across all categories of BMI in men and women, with modest heterogeneity in men. Handgrip strength was associated with cardiovascular mortality in men only (HR tertile 1 vs. tertile 3 = 1.38; 1.18–1.62), without differences across BMI categories, while associations with all-cause mortality were only seen in men with low BMI. Associations for walking pace and handgrip strength with cancer mortality were less consistent. CONCLUSION A simple self-reported measure of slow walking pace could aid risk stratification for all-cause and cardiovascular mortality within the general population.

History

Citation

European Heart Journal, 2017, 38 (43), pp. 3232–3240

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine

Version

AM (Accepted Manuscript)

Published in

European Heart Journal

Publisher

Oxford University Press for European Society of Cardiology

issn

0195-668X

eissn

1522-9645

Acceptance date

17/07/2017

Copyright date

2017

Available date

21/08/2018

Publisher version

https://academic.oup.com/eurheartj/search-results?page=1&q=Association of walking pace and handgrip strength with all-cause, cardiovascular and cancer mortality: A UK Biobank observational study&fl_SiteID=5375&allJournals=1&SearchSourceType=1

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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