PIIS0021915018302120.pdf (1.61 MB)
Download file

Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.

Download (1.61 MB)
journal contribution
posted on 23.07.2018, 15:55 by Linda M. O'Keeffe, Laura D. Howe, Abigail Fraser, Alun D. Hughes, Kaitlin H. Wade, Emma L. Anderson, Debbie A. Lawlor, A. Mesut Erzurumluoglu, George Davey-Smith, Santiago Rodriguez, Evie Stergiakouli
BACKGROUND AND AIMS: Males have greater cardiometabolic risk than females, though the reasons for this are poorly understood. The aim of this study was to examine the association between common Y chromosomal haplogroups and cardiometabolic risk during early life. METHODS: In a British birth cohort, we examined the association of Y chromosomal haplogroups with trajectories of cardiometabolic risk factors from birth to 18 years and with carotid-femoral pulse wave velocity, carotid intima media thickness and left ventricular mass index at age 18. Haplogroups were grouped according to their phylogenetic relatedness into categories of R, I, E, J, G and all other haplogroups combined (T, Q, H, L, C, N and O). Risk factors included BMI, fat and lean mass, systolic blood pressure (SBP), diastolic blood pressure, pulse rate, triglycerides, high density lipoprotein cholesterol (HDL-c), non-HDL-c and c-reactive protein. Analyses were performed using multilevel models and linear regression, as appropriate. RESULTS: Y chromosomal haplogroups were not associated with any cardiometabolic risk factors from birth to 18 years. For example, at age 18, the difference in SBP comparing each haplogroup with haplogroup R was -0.39 mmHg (95% Confidence Interval (CI): -0.75, 1.54) for haplogroup I, 2.56 mmHg (95% CI: -0.76, 5.89) for haplogroup E, -0.02 mmHg (95% CI: -2.87, 2.83) for haplogroup J, 1.28 mmHg (95% CI: -4.70, 2.13) for haplogroup G and -2.75 mmHg (95% CI: -6.38, 0.88) for all other haplogroups combined. CONCLUSIONS: Common Y chromosomal haplogroups are not associated with cardiometabolic risk factors during childhood and adolescence or with subclinical cardiovascular measures at age 18.

Funding

We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and will serve as guarantors for the contents of this paper. This research was specifically funded UK Medical Research Council Population Health Scientist fellowship (MR/M014509/1) granted to LMOK.

History

Citation

Atherosclerosis, 2018, 274, pp. 94-103

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

VoR (Version of Record)

Published in

Atherosclerosis

Publisher

Elsevier. European Atherosclerosis Society, International Atherosclerosis Society, Society of Atherosclerosis Imaging and Prevention

eissn

1879-1484

Acceptance date

24/04/2018

Copyright date

2018

Available date

23/07/2018

Publisher version

https://www.sciencedirect.com/science/article/pii/S0021915018302120?via=ihub

Notes

Supplementary data related to this article can be found at https://doi.org/10.1016/j.atherosclerosis.2018.04.027

Language

en

Usage metrics

Categories

Licence

Exports