Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis..pdf (324.4 kB)
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Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

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journal contribution
posted on 24.10.2012, 09:16 by Edward J. Hollox, J. Davies, U. Griesenbach, J. Burgess, E. W. Alton, J. A. Armour
Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy number between 2 and 12 in different individuals. We determined the copy number of this locus in 355 patients with cystic fibrosis (CF), and tested for correlation between beta-defensin cluster genomic copy number and lung disease associated with CF. No significant association was found.

History

Citation

Journal of Negative Results in BioMedicine, 2005, 4, pp. 9-9

Published in

Journal of Negative Results in BioMedicine

Publisher

BioMed Central

eissn

1477-5751

Copyright date

2005

Available date

24/10/2012

Publisher version

http://jnrbm.biomedcentral.com/articles/10.1186/1477-5751-4-9

Language

eng