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Biomechanical modelling of spinal tumor anisotropic growth

journal contribution
posted on 05.06.2020, 09:45 by Ioanna Katsampa, Pavlos Evangelides, Chrysovalantis Voutouri, Alkiviadis Tsamis, Vasileios Vavourakis, Triantafyllos Stylianopoulos
Biomechanical abnormalities of solid tumours involve stiffening of the tissue and accumulation of mechanical stresses. Both abnormalities affect cancer cell proliferation and invasiveness and thus, play a crucial role in tumour morphology and metastasis. Even though, it has been known for more than two decades that high mechanical stresses reduce cancer cell proliferation rates driving growth towards low-stress regions, most biomechanical models of tumour growth account for isotropic growth. This cannot be valid, however, in tumours that grow within multiple host tissues of different mechanical properties, such as the spine. In these cases, structural heterogeneity would result in anisotropic growth of tumours. To this end, we present a biomechanical, biphasic model for anisotropic growth of spinal tumours. The model that accounts for both the fluid and the solid phase of the tumour was used to predict the evolution of solid stress and interstitial fluid pressure in intramedullary spinal tumours and highlight the differences between isotropic and anisotropic growth. Varying the degree of anisotropy, we found considerable differences in the shape of the tumours, leading to tumours of more realistic ellipsoidal shapes.

History

Citation

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2020, 476(2238), 20190364

Version

AM (Accepted Manuscript)

Published in

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volume

476

Issue

2238

Pagination

20190364

Publisher

Royal Society, The

issn

1364-5021

eissn

1471-2946

Acceptance date

01/05/2020

Copyright date

2020

Notes

All data supporting the findings of this study are available in the paper and the Supplement. The COMSOL code is available at https://doi.org/10.5281/zenodo.3688265

Language

en

Publisher version

TBA