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Birth weight centiles and small for gestational age (SGA) by sex and ethnicity for England and Wales

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journal contribution
posted on 31.05.2019, 10:11 by A Hansell, A Freni-Sterrantino, P Afoakwah, RB Smith, RE Ghosh
Objectives To construct UK Ethnic Birth Weight Centiles (UK-EBWC) for gestational age and cutoffs for small for gestational age (SGA) for England and Wales and to evaluate the SGA misclassification using the UK centiles. Design Analysis of national birth data. Participants All live singleton births in England and Wales in 2006 to 2012, as recorded by the Office for National Statistics (ONS) and birth registrations, linked with National Health Service (NHS) into Numbers for Babies (NN4B). Main Outcome Measures Both sex-specific and ethnicity-sex-specific birth weight centiles for gestational age, and ethnicity-sex-specific SGA cut-offs. Centiles were computed using the Generalized Additive Model for Location, Scale and Shape (GAMLSS). Results Our sex-specific centiles performed well and showed an agreement between the expected and observed number of births below the centiles. The ethnicity-sex-specific centiles for Black and Asian presented lower values compared to the White centiles. Comparisons of sex-specific and ethnicity-sex-specific centiles shows that use of sex-specific centiles increases the SGA diagnosed cases by 50% for Asian, 30% for South Asian (Indian, Pakistani and Bangladeshi) and 20% for Black ethnicity. Conclusions The centiles show important differences between ethnic groups, in particular the 10th centile used to define SGA. To account for these differences and to minimize misclassification of SGA, we recommend the use of customized birth weight centiles .

Funding

The UK Small Area Health Statistics Unit (SAHSU) is part of the MRC-PHE Centre for Environment and Health, which is supported by the Medical Research Council (MR/L01341X/1) and Public Health England (PHE). The research was funded/part funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Health Impact of Environmental Hazards at King’s College London in partnership with Public Health England (PHE) and Imperial College London.

History

Citation

Archives of Disease in Childhood, 2019

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Health Sciences

Version

AM (Accepted Manuscript)

Published in

Archives of Disease in Childhood

Publisher

BMJ Publishing Group for Royal College of Paediatrics and Child Health, European Academy of Paediatrics

issn

0003-9888

Acceptance date

22/05/2019

Copyright date

2019

Available date

18/09/2019

Publisher version

https://adc.bmj.com/content/early/2019/06/13/archdischild-2018-316518

Language

en