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Brain tissue pulsation in healthy volunteers

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journal contribution
posted on 05.10.2020, 12:29 by P Turner, C Banahan, M Alharbi, S Venturini, S Berger, I Bnini, J Campbell, KW Beach, M Horsfield, M Oura, Andrea Lecchini Visintini, EML Chung
It is well known that the brain pulses with each cardiac cycle, but interest in measuring cardiac-induced brain tissue pulsations (BTPs) is relatively recent. This study was aimed at generating BTP reference data from healthy patients for future clinical comparisons and modelling. BTPs were measured through the forehead and temporal positions as a function of age, sex, heart rate, mean arterial pressure and pulse pressure. A multivariate regression model was developed based on transcranial tissue Doppler BTP measurements from 107 healthy adults (56 male) aged from 20–81 y. A subset of 5 participants (aged 20–49 y) underwent a brain magnetic resonance imaging scan to relate the position of the ultrasound beam to anatomy. BTP amplitudes were found to vary widely between patients (from ∼4 to ∼150 µm) and were strongly associated with pulse pressure. Comparison with magnetic resonance images confirmed regional variations in BTP with depth and probe position.

History

Citation

Ultrasound in Medicine and Biology, 2020, https://doi.org/10.1016/j.ultrasmedbio.2020.08.020

Author affiliation

Department of Cardiovascular Sciences

Version

AM (Accepted Manuscript)

Published in

Ultrasound in Medicine and Biology

Publisher

Elsevier

issn

0301-5629

Acceptance date

20/08/2020

Copyright date

2020

Available date

24/09/2021

Language

en