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COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

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posted on 20.09.2022, 09:57 authored by Gita A Pathak, Renato Polimanti, Juha Karjalainen, Mark Daly, Andrea Ganna, Mark J Daly, Christine Stevens, Masahiro Kanai, Rachel G Liao, Amy Trankiem, Mary K Balaconis, Huy Nguyen, Matthew Solomonson, Kumar Veerapen, Samuli Ripatti, Lindo Nkambul, Sam Bryant, Vijay G Sankaran, Benjamin M Neale, Konrad J Karczewski, Alicia R Martin, Elizabeth G Atkinson, Kristin Tsuo, Nikolas Baya, Patrick Turley, Rahul Gupta, Raymond K Walters, Duncan S Palmer, Gopal Sarma, Nathan Cheng, Wenhan Lu, Claire Churchhouse, Jacqueline Goldstein, Daniel King, Wei Zhou, Cotton Seed, Hilary Finucane, F Kyle Satterstrom, Shea J Andrews, Laura G Sloofman, Stuart C Sealfon, Clive Hoggart, Slayton J Underwood, Mattia Cordioli, Matti Pirinen, Kati Donner, Katja Kivinen, Aarno Palotie, Mari Kaunisto, Nadia Harerimana, Karolina Chwialkowska, Brooke Wolford, Genevieve Roberts, Danny Park, Catherine A Ball, Marie Coignet, Shannon McCurdy, Spencer Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Milos Pavlovic, Eurie L Hong, Kristin Rand, Ahna Girshick, Harendra Guturu, Asher Haug Baltzell, Mari EK Niemi, Sara Pigazzini, Souad Rahmouni, Michel Georges, Yasmine Belhaj, Julien Guntz, Sabine Claassen, Yves Beguin, Stephanie Gofflot, Lindokuhle Nkambule, Lindokuhle Nkambul, Caroline Cusick, Michel Moutschen, Benoit Misset, Gilles Darcis, Julien Guiot, Samira Azarzar, Olivier Malaise, Pascale Huynen, Christelle Meuris, Marie Thys, Jessica Jacques, Philippe Leonard, Frederic Frippiat, Jean-Baptiste Giot, Anne-Sophie Sauvage, Christian Von Frenckell, Bernard Lambermont, Tomoko Nakanishi, David R Morrison, J Brent Richards, Guillaume Butler-Laporte, Vincenzo Forgetta, Biswarup Ghosh, Laetitia Laurent, Danielle Henry, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Branka Vulesevic, Meriem Bouab, Charlotte Guzman, Louis Petitjean, Chris Tselios, Xiaoqing Xue, Jonathan Afilalo, Darin Adra, Vincent Mooser, Rui Li, Alexandre Belisle, Pierre Lepage, Jiannis Ragoussis, Daniel Auld, G Mark Lathrop, Marc Afilalo, Maureen Oliveira, Bluma Brenner, Nathalie Brassard, Madeleine Durand, Michael Chasse, Daniel E Kaufmann, Erwin Schurr, Caroline Hayward, Anne Richmond, J Kenneth Baillie, Joseph T Glessner, Hakon Hakonarson, Xiao Chang, Douglas M Shaw, Jennifer Below, Hannah Polikowski, Petty E Lauren, Hung-Hsin Chen, Wanying Zhu, Lea Davis, V Eric Kerchberger, Archie Campbell, David J Porteous, Chloe Fawns-Ritchie, Marcela Morris, Joseph B McCormick, Kari North, Joseph R Glessner, Christopher R Gignoux, Stephen J Wicks, Kristy Crooks, Kathleen C Barnes, Michelle Daya, Jonathan Shortt, Nicholas Rafaels, Sameer Chavan, Paul RHJ Timmers, James F Wilson, Albert Tenesa, Shona M Kerr, Kenton D'Mellow, Doaa Shahin, Yasser M El-Sherbiny, Jehan J El-Jawhari, Kathrin Aprile von Hohenstaufen, Ali Sobh, Madonna M Eltoukhy, Attia AS Mohamed, Tamer A Elhadidy, Mohamed S Abd Elghafar, Marwa H Elnagdy, Amr Samir, Mohamed AF Hegazy, Mahmoud Abdel-Aziz, Walid T Khafaga, Walaa M El-Lawaty, Mohamed S Torky, Hanteera S Moahmed, Mohamed R El-shanshory, Amr M Yassen, Kamal Okasha, Mohammed A Eid, Carolina Medina-Gomez, Andre G Uitterlinden, M Arfan Ikram, Reedik Magi, Lili Milani, Andres Metspalu, Triin Laisk, Kristi Lall, Maarja Lepamets, Tonu Esko, Ene Reimann, Helene Alavere, Kristjan Metsalu, Mairo Puusepp, Paul Naaber, Edward Laane, Jaana Pesukova, Part Peterson, Kai Kisand, Jekaterina Tabri, Raili Allos, Kati Hensen, Joel Starkopf, Inge Ringmets, Anu Tamm, Anne Kallaste, Chiara Batini, Martin D Tobin, Laura D Venn, Paul H Lee, Nick Shrine, Alexander T Williams, Anna L Guyatt, Catherine John, Richard J Packer, Altaf Ali, Xueyang Wang, Louise Wain, Catherine E Bee, Emma L Adams, Robert C Free, Edward J Hollox, Sanni Ruotsalainen, Kati Kristiansson, Sami Koskelainen, Markus Perola, Carlo Rivolta, Mathieu Quinodoz, Dhryata Kamdar, Pierre-Yves Bochud, Noemie Boillat, Stephanie Bibert, Semira Gonseth Nussle, Werner Albrich, Noemie Suh, Dionysios Neofytos, Veronique Erard, Cathy Voide, R Friolet, P Vollenweider, JL Pagani, M Oddo, F Meyer zu Bentrup, A Conen, O Clerc, O Marchetti, A Guillet, C Guyat-Jacques, S Foucras, M Rime, J Chassot, M Jaquet, R Merlet Viollet, Y Lannepoudenx, L Portopena, PY Bochud, F Desgranges, P Filippidis, B Guery, D Haefliger, EE Kampouri, O Manuel, A Munting, M Papadimitriou-Olivgeris, J Regina, L Rochat-Stettler, V Suttels, E Tadini, J Tschopp, M Van Singer, B Viala, N Boillat-Blanco, T Brahier, O Hugli, JY Meuwly, O Pantet, S Gonseth Nussle, M Bochud, V D'Acremont, S Estoppey Younes, WC Albrich, N Suh, A Cerny, L O'Mahony, C von Mering, M Frischknecht, G-R Kleger, M Filipovic, CR Kahlert, H Wozniak, T Rochat Negro, J Pugin, K Bouras, C Knapp, T Egger, A Perret, P Montillier, C di Bartolomeo, B Barda, Rafael de Cid, Anna Carreras, Ivan Galvan-Femenia, Natalia Blay, Xavier Farre, Lauro Sumoy, Beatriz Cortes, Victor Moreno, Manolis Kogevinas, Judith Garcia-Aymerich, Gemma Castano-Vinyals, Carlota Dobano, Josep Maria Mercader, Josep Mercader, Marta Guindo-Martinez, David Torrents, Marco Gori, Nicola Picchiotti, Marco Tanfoni, Alessandra Renieri, Francesca Mari, Chiara Fallerini, Sergio Daga, Margherita Baldassarri, Francesca Fava, Elisa Frullanti, Floriana Valentino, Gabriella Doddato, Annarita Giliberti, Mirella Bruttini, Susanna Croci, Ilaria Meloni, Giada Beligni, Laura Di Sarno, Maria Palmieri, Miriam Lucia Carriero, Diana Alaverdian, Rossella Tita, Sara Amitrano, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Francesca Montagnani, Mario Tumbarello, Simone Furini, Elisa Benetti, Kristina Zguro, Katia Capitani, Francesco Bianchi, Mirjam Lista, Mario Umberto Mondelli, Raffaele Bruno, Francesco Castelli, Eugenia Quiros-Roldan, Melania Degli Antoni, Massimo Vaghi, Stefano Rusconi, Agostino Riva, Matteo Siano, Arianna Gabrieli, Massimiliano Fabbiani, Barbara Rossetti, Ilaria Rancan, Elena Bargagli, Laura Bergantini, Miriana D'Alessandro, Paolo Cameli, David Bennett, Federico Franchi, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Maria Antonietta Mazzei, Susanna Guerrini, Luca Cantarini, Edoardo Conticini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Maria Bandini, Paolo Piacentini, Elena Desanctis, Silvia Cappelli, Gian Piero Caldarelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Agostino Ognibene, Alessandro Pancrazzi, Maria Lorubbio, Antonella D'Arminio Monforte, Federica Gaia Miraglia, Massimo Girardis, Stefano Busani, Sophie Venturelli, Andrea Antinori, Arianna Emiliozzi, Alessandra Vergori, Daniela Francisci, Elisabetta Schiaroli, Andrea Tommasi, Francesco Paciosi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Renzo Scaggiante, Francesca Gatti, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Merla, Giuseppe Fiorentino, Marco Castori, Massimo Carella, Filippo Aucella, Antonio Di Biagio, Matteo Bassetti, Luca Masucci, Maurizio Sanguinetti, Alessandra Guarnaccia, Serafina Valente, Oreste De Vivo, Marco Mandala, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, Ferdinando Giannattasio, Tullio Trotta, Gabriella Coiro, Domenico A Coviello, Cristina Mussini, Luisa Tavecchia, Mary Ann Belli, Sandro Mancarella, Lia Crotti, Gianfranco Parati, Marco Rizzi, Franco Maggiolo, Diego Ripamonti, Maria Teresa La Rovere, Simona Sarzi-Braga, Maurizio Bussotti, Sabrina Ravaglia, Rosangela Artuso, Elena Andreucci, Antonio Perrella, Davide Romani, Paola Bergomi, Emanuele Catena, Riccardo Colombo, Antonella Vincenti, Claudio Ferri, Davide Grassi, Gloria Pessina, Monica Poscente, Massimo Di Pietro, Ravaglia Sabrina, Sauro Luchi, Simona Dei, Maurizio Sanarico, Chiara Gabbi, Stefano Ceri, Pietro Pinoli, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Marco Vecchia, Stefania Mantovani, Serena Ludovisi, Isabella Zanella, Andrea Cossarizza, Saverio Giuseppe Parisi, Stefano Baratti, Gabriella Maria Squeo, Pamela Raggi, Carmen Marciano, Rita Perna, Elisabetta Menatti

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.

History

Author affiliation

Department of Health Sciences, University of Leicester

Version

VoR (Version of Record)

Published in

NATURE

Volume

608

Issue

7921

Pagination

E1–E10

Publisher

NATURE PORTFOLIO

issn

0028-0836

eissn

1476-4687

Copyright date

2022

Available date

20/09/2022

Spatial coverage

England

Language

English