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Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

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posted on 21.04.2016, 09:52 by H. Plun-Favreau, P. A. Lewis, J. Hardy, L. Miguel Martins, N. W. Wood
Cancer and neurodegeneration are often thought of as disease mechanisms at opposite ends of a spectrum; one due to enhanced resistance to cell death and the other due to premature cell death. There is now accumulating evidence to link these two disparate processes. An increasing number of genetic studies add weight to epidemiological evidence suggesting that sufferers of a neurodegenerative disorder have a reduced incidence for most cancers, but an increased risk for other cancers. Many of the genes associated with either cancer and/or neurodegeneration play a central role in cell cycle control, DNA repair, and kinase signalling. However, the links between these two families of diseases remain to be proven. In this review, we discuss recent and sometimes as yet incomplete genetic discoveries that highlight the overlap of molecular pathways implicated in cancer and neurodegeneration.

History

Citation

PLOS Genetics, 2010, 6 (12), e1001257

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biology

Version

VoR (Version of Record)

Published in

PLOS Genetics

Publisher

Public Library of Science

issn

1553-7390

eissn

1553-7404

Copyright date

2010

Available date

21/04/2016

Publisher version

http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001257

Language

en