Review CVD and exercise.pdf (222.97 kB)
Download file

Cardiovascular adaptations associated with exercise in patients on hemodialysis.

Download (222.97 kB)
journal contribution
posted on 11.06.2019, 08:58 by Matthew P. M. Graham-Brown, Meg J. Jardine, James O. Burton
Patients on hemodialysis are physically inactive. Less than 50% of hemodialysis patients undertake exercise once a week and such patients have increased mortality compared to patients who undertake regular exercise. The reasons for physical inactivity and reduced functional capacity are complex and inter-related, with skeletal muscle catabolism, chronic inflammation, anemia, malnutrition, uremia, the burden of co-morbid diseases, and "enforced" sedentary time during hemodialysis all contributing. Many of these factors drive cardiovascular disease (CVD) processes in this cohort of patients and in the general population, exercise interventions have been shown to modify many of these risk factors. Whilst there is increasing evidence about the beneficial effects of exercise interventions on quality of life, functional capacity, aerobic fitness, and muscular strength, there are few compelling data on the effects of such programs on cardiovascular outcome measures. The reasons for this are manifold and include: limitations in study size; inconsistencies in study design; the heterogeneous nature of exercise interventions; assessment of nonstandardized outcome measures and; a lack of understanding of what changes in certain traditional measures of CVD (such as blood pressure or lipid profile) mean for patients on hemodialysis. This review summarizes the current evidence base for the effects of exercise on traditional and nontraditional cardiovascular risk factors and the effects of exercise interventions on cardiovascular structure and function, including a review of study limitations and future research priorities.

History

Citation

Seminars in Dialysis, 2019

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation

Version

AM (Accepted Manuscript)

Published in

Seminars in Dialysis

Publisher

Wiley

eissn

1525-139X

Copyright date

2019

Publisher version

https://onlinelibrary.wiley.com/doi/full/10.1111/sdi.12789

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

Usage metrics

Categories

Keywords

Exports